By Thomas Ming Swi Chang
This can be a finished and primary type assessment of approximately all very important and basic advancements of artifiical cells via the nestor of this department in utilized biomedial technology himself. This "bible" is vital interpreting for either newcomers and the skilled specialist. Chang wrote an excellent and stimulating evaluate over 50 years of man-made mobile learn and improvement and purposes.
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Extra info for Artificial Cells: Biotechnology, Nanomedicine, Regenerative Medicine, Blood Substitutes, Bioencapsulation, Cell/Stem Cell Therapy (Regenerative Medicine, Artificial Cells and Nanomedicine)
Artiﬁcial cells can contain an unlimited variety of material individually or in combinations (Fig. 1). These include cells, stem cells, enzymes, multienzyme systems, hemoglobin, magnetic materials, microorganisms, vaccines, genes for gene therapy, genetically engineered cells, adsorbents, drugs, hormones, peptides, proteins and others. The following is a brief overview of some of examples that illustrate the basic principles. Later chapters contain detailed references and descriptions. ch02 FA April 2, 2007 12:8 SPI-B446 Artiﬁcial Cells: Biotechnology, Nanotechnology, Blood Substitutes, Regenerative...
Developing these for actual clinical use required parallel developments in molecular biology and biotechnology that were not yet available. More recently, many groups around the world have made exciting progress in biotechnology, molecular biology, genetic engineering and related areas. The outcome is a recent new wave of research and development in artiﬁcial cells. , 2003; Chang, 2005). Later chapters will describe some of these in more detail. This is now such a broad area that space will only allow for review of these areas with detailed examples based on research in my laboratory.
Ch02 FA April 2, 2007 12:8 SPI-B446 Artiﬁcial Cells: Biotechnology, Nanotechnology, Blood Substitutes, Regenerative... Basic Principles 17 waiting for typing and crossmatching in the hospital. They are also free from infective agents such as HIV, hepatitis C, bacteria, parasites and so on. Furthermore, whereas donor blood has to be stored at 4◦ C and is only good for 42 days, PolyHb can be stored at room temperature for more than a year. Thus, PolyHb can have important uses in a number of clinical conditions notably for surgery.