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By Shaker A. Mousa

1This choice of overview articles highlights the newest improvement of antithrombotics and gives confirmed experimental equipment for the extra improvement of latest and greater anticoagulants. one of the state of the art advancements reviewed are the radical utilization of low molecular weight heparins, such antithrombin brokers because the hirudin, and such antiplatelet medications because the GPIIb/IIIa inhibitors and ADP receptor antagonists. extra strategies mentioned comprise aspirin and clopidogrel, the accelerated use of polytherapeutic methods, antiproteases (factors IIa, Xa, and VIIa), tissue issue focusing on, platelet receptor concentrating on, and antithrombin III modulation.

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Extra info for Anticoagulants, Antiplatelets, and Thrombolytics (Methods in Molecular Medicine)

Example text

In contrast, positions farther downstream are avoided in order to minimize the effects of upstream platelet adhesion, and subsequent aggregation on both the fluid dynamic environment as well as bulk platelet concentration. 7. The digitization of a background image (at the onset of perfusion prior to platelet adhesion to the collagen I surface) and its subtraction from a subsequent image acquired 5-s after an initial platelet adhesion event allows the determination of the fluorescence intensity emitted by a single platelet.

85, 491–493. 12. Gear, A. R. L. and Lambrecht, J. K. (1981) Reduction in single platelets during primary and secondary aggregation. Thromb. Haemostasis 45, 298. 13. Peterson, D. , Stathopoulos, N. , Giorgio, T. D, Hellums, J. , and Moake, J. L. (1987) Shear-induced platelet aggregation requires von Willebrand factor and platelet membrane glycoproteins Ib and IIb-IIIa. Blood 69, 625–628. 14. Jen, C. J. and McIntire, L. V. (1984) Characteristics of shear-induced aggregation in whole blood. J. Lab.

25. Giugliano, R. , Roe, M. , et al. (2001) Restoration of epicardial and myocardial perfusion in acute ST-elevation myocardial infarction with combination eptifibatide and reduced dose tenecteplase: dose finding results from the INTEGRITI Trial (abstract). Circulation 104, II–538, 2001. 26. , Giugliano, R. , and Antman, E. M. (2001) Bolus fibrinolytic therapy in acute myocardial infarction. JAMA 286, 442–449. 27. Brener, S. , Adgey, A. , et al. (2002) Eptifibatide and low dose tissue plasminogen activator in acute myocardial infarction: the integrelin and low dose thrombolysis in acute myocardial infarction (INTRO-AMI) Trial.

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