By Bruce C Baguley; David J Kerr
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Extra resources for Anticancer drug development
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1996). Both of these pathways are involved in mitogenesis and cell survival. 34 LEOPOLD ET AL. B. , 1994; Depotter, 1994; Hynes and Stern, 1994; Davies and Chamberlin, 1996; Qian and Greene, 1997). , 1994). , 1997). , 1996). , 1995). These data, coupled with the fact that the tyrosine kinase activity is absolutely required for their mitogenic and transforming properties, provide a strong rationale to focus on these receptors as viable targets for cancer chemotherapy. Thus far two approaches have been taken to attack this family of receptors on tumors.
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