Download Advances in Drug Delivery Systems, 6. Proceedings of the by James M. Anderson PDF

By James M. Anderson

The forefront technology offered at this symposium represents the easiest of overseas pharmaceutics, polymer technological know-how, biotechnology, molecular biology and mobilephone biology examine efforts. The booklet emphasises the next components of drug supply learn: more suitable equipment of healing management, specially for proteins and peptides; novel supply structures; complicated provider and concentrating on structures; and new healing recommendations and service, receptor and mobile interactions and mechanisms for healing functions

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Read Online or Download Advances in Drug Delivery Systems, 6. Proceedings of the Sixth International Symposium on Recent Advances in Drug Delivery Systems, Salt Lake City, UT, U.S.A., February 21–24, 1993 PDF

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Additional resources for Advances in Drug Delivery Systems, 6. Proceedings of the Sixth International Symposium on Recent Advances in Drug Delivery Systems, Salt Lake City, UT, U.S.A., February 21–24, 1993

Example text

The mucosa of the oral cavity can be generally divided into two categories, keratinized (gingiva and palate) and nonkeratinized epithelial tissues (sublingual and buccal). Transbuccal administration offers several ad­ vantages for controlled drug delivery. Buccal ab­ sorption bypasses hepatic first pass metabolism and, although tissue metabolism can occur [1,2], this presystemic metabolism is considerably less than that encountered in the gastrointestinal tract, especially in the case of peptide drugs.

Transparent within 30 min. Insoluble perm-se­ lective membranes were removed at 5-6 h. The condition of the mucosa was assessed as noted above. Results and Discussion Transmucosal absorption of LMWH was in­ vestigated using the dog buccal mucosa model. The dog was selected as an animal model be­ cause the structure of dog buccal tissue is histologically similar to human tissue [18]. Rodents tend to have keratinized buccal tissue while dogs, like humans, show well vascularized buccal tis­ sue with no keratinized layer.

These results show that in the case of heparin absorption, enhancement activity and tissue damage are not necessarily related. Based on these results, Na taurocholate was selected for further evaluation. Intersubject variability in LMWH absorption using Na taurocholate is shown in Fig. 4. Al­ though the three curves are remarkably similar in terms of blood levels achieved, the calculated maximum amounts absorbed varied three-fold from 1070 to 3467 IU (Fig. 5) for these single dose experiments. After an initial lag time, drug was absorbed at a fairly constant rate during the 90 min in which the diffusion cell was applied.

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