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It is not yet known whether the heat induction procedure results in the detachment of an integrated viral genome (see Section V,B) prior to capsid antigen synthesis. , 1968b). However, distinctive genetic markers were not available for these studies. In one interesting exception (Todaro and Takemoto, 1969), rescued virus was more efficient at transformation than the parental type. The authors postulated that the enhanced efficiency of transformation of the rescued virus could be due either to a selection of more efficient transforming viruses from the original stock or to some host-induced modification of the virus.
There is no direct evidence available that the infectious virus recovered in any of the rescue experiments is the virus responsible for the transformation event, the genome of which has been excised from integration and replicated. Extrachromosomal copies of the virus may exist, and these may be detected in the virus recovery attempts. Rescue experiments to date have not succeeded in eliciting infectious virus from more than a minor proportion of a transformed cell population. One type of PAPOVAVIRUS SV40 35 evidence which would be supportive would be the isolation of specialized transducing particles containing a portion of the viral genome linked to a region of the host cell DNA.
S. BUTEL, S. S. TEVETHIA, AND J . L. MELNICK It is also possible that, upon infection of hamster cells, SV40 either directly or indirectly activates an unrelated virus previously latent in the hamster cells (Huebner and Todaro, 1969), which, in turn, is responsible for the membrane reaction. Another possibility is that cells infected with SV40 may undergo abortive transformation, but in the process conditions are altered such that S-antigen synthesis is initiated. A recent report (Vasconcelos-Costa, 1970) indicated that cells transformed by adenovirus 12 may lose T-antigen but retain S-antigen.